DNA adducts produced by oils, oil fractions and polycyclic aromatic hydrocarbons in relation to repair processes and skin carcinogenesis

2000 ◽  
Vol 20 (3) ◽  
pp. 165-174 ◽  
Author(s):  
Andrew J. Ingram ◽  
John C. Phillips ◽  
Scott Davies
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Dna Adducts ◽  
Aromatic Hydrocarbons ◽  
Skin Carcinogenesis ◽  
Repair Processes ◽  
Oil Fractions ◽  
Polycyclic Aromatic

DNA Adducts Formed bysynDihydrodiol Epoxides of Polycyclic Aromatic Hydrocarbons

1994 ◽  
Vol 6 (1-4) ◽  
pp. 87-93 ◽  
Author(s):  
Jan Szeliga ◽  
Bruce D. Hilton ◽  
Hongmee Lee ◽  
Ronald G. Harvey ◽  
Anthony Dipple
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Dna Adducts ◽  
Aromatic Hydrocarbons ◽  
Polycyclic Aromatic

scholarly journals Association of polycyclic aromatic hydrocarbons in moss with blood biomarker among nearby residents in Portland, Oregon

2021 ◽  
Author(s):  
Igor Burstyn ◽  
Geoffrey H. Donovan ◽  
Yvonne L. Michael ◽  
Sarah Jovan
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Air Quality ◽  
Dna Adducts ◽  
Aromatic Hydrocarbons ◽  
Human Health Risk ◽  
Monitoring Methods ◽  
Wood Fire ◽  
Individual Determinants ◽  
Polycyclic Aromatic ◽  
Environmental Air

Polycyclic aromatic hydrocarbons (PAHs) are a component of air pollutants that are costly to measure using traditional air-quality monitoring methods. We used an epiphytic bio-indicator (moss genus: Orthotrichum) to cost-effectively evaluate atmospheric deposition of PAHs in Portland, Oregon in May 2013. However, it is unclear if measurements derived from these bioindicators are good proxies for human exposure. To address this question, we simultaneously, measured PAH-DNA adducts in blood samples of non-smokers residing close to the sites of moss measurements. We accounted for individual determinants of PAH uptake that are not related to environmental air quality through questionnaires, e.g., wood fires, consumption of barbecued and fried meats. Correlation and linear regression (to control for confounders from the lifestyle factors) evaluated the associations. We did not observe evidence of an association between PAH levels in moss and PAH-DNA adducts in blood of nearby residents, but higher level of adduct were evident in those who used wood fire in their houses in the last 48 hours. It remains to be determined whether bio-indicators in moss can be used for human health risk assessment.

scholarly journals Cancer initiation by polycyclic aromatic hydrocarbons results from formation of stable DNA adducts rather than apurinic sites

1999 ◽  
Vol 20 (10) ◽  
pp. 1885-1891 ◽  
Author(s):  
Victor J. Melendez-Colon ◽  
Andreas Luch ◽  
Albrecht Seidel ◽  
William M. Baird
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Dna Adducts ◽  
Aromatic Hydrocarbons ◽  
Cancer Initiation ◽  
Polycyclic Aromatic

scholarly journals Prenatal Exposure to Polycyclic Aromatic Hydrocarbons, Benzo[a]pyrene–DNA Adducts, and Genomic DNA Methylation in Cord Blood

2012 ◽  
Vol 120 (5) ◽  
pp. 733-738 ◽  
Author(s):  
Julie B. Herbstman ◽  
Deliang Tang ◽  
Deguang Zhu ◽  
Lirong Qu ◽  
Andreas Sjödin ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Polycyclic Aromatic Hydrocarbons ◽  
Cord Blood ◽  
Prenatal Exposure ◽  
Dna Adducts ◽  
Aromatic Hydrocarbons ◽  
Genomic Dna ◽  
Polycyclic Aromatic

Seasonal variations of DNA adducts in mothers and newborns exposed to polycyclic aromatic hydrocarbons in Mexico City

2016 ◽  
Vol 259 ◽  
pp. S78
Author(s):  
J.A. Maciel-Ruiz ◽  
C. López-Rivera ◽  
R. Robles ◽  
M.G. Veloz-Martínez ◽  
P. Petrosyan ◽  
...  
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Mexico City ◽  
Dna Adducts ◽  
Aromatic Hydrocarbons ◽  
Seasonal Variations ◽  
Polycyclic Aromatic

scholarly journals Serum Level of Antibodies (IgG, IgM) Against Benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA Adducts in Children Dermatologically Exposed to Coal Tar

2017 ◽  
Vol 60 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Pavel Borský ◽  
Ctirad Andrýs ◽  
Jan Krejsek ◽  
Květoslava Hamáková ◽  
Jan Kremláček ◽  
...  
Keyword(s):  
Immune Response ◽  
Polycyclic Aromatic Hydrocarbons ◽  
Serum Level ◽  
Dna Adducts ◽  
Aromatic Hydrocarbons ◽  
Coal Tar ◽  
Reactive Metabolite ◽  
Potential Biomarker ◽  
Polycyclic Aromatic ◽  
Dermal Application

Crude coal tar (CCT) contains polycyclic aromatic hydrocarbons (PAHs). Benzo[a]pyrene (BaP) is metabolized into a highly reactive metabolite benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE) that is able to bind to DNA and creates BPDE-DNA adducts. Adducted DNA becomes immunogenic and induces immune response by production of antibodies against BPDE-DNA adducts (Ab-BPDE-DNA). Circulating Ab-BPDE-DNA was proposed as potential biomarker of genotoxic exposure to BaP (PAHs). Goeckerman therapy (GT) of psoriasis uses dermal application of CCT ointment (PAHs). In presented study (children with psoriasis treated by GT; n = 19) the therapy significantly increased the level of Ab-BPDE-DNA (EI = 0.29/0.19–0.34 vs. 0.31/0.25–0.40; median/lower–upper quartile; p < 0.01). The results support the idea of Ab-BPDE-DNA level as a possible tentative indicator of exposure, effects and susceptibility of the organism to the exposure of BaP (PAHs).

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